Unlocking the Potential: A Review of Stem Cell Applications in Regenerative Medicine

Published19-01-2024

Abstract

Background:Regenerative medicine stands at the forefront of transformative healthcare, offering innovative approaches to address tissue damage and degenerative conditions. Central to this paradigm is the profound impact of stem cell therapy, a dynamic and promising avenue within regenerative medicine. As we navigate the complexities of this evolving field, our systematic literature review seeks to unravel the diverse applications, breakthroughs, and challenges inherent in utilizing stem cells for regenerative purposes

Methods: We searched in Science direct, Pubmed, NIH and another e-library with keyword stem cell, application and regenerative medicine. Our review aims to contribute to the ongoing narrative of stem cell therapy in regenerative medicine. Through this exploration, we aspire not only to enhance our understanding but also to guide future research endeavors and clinical applications in this dynamic and promising field.

Results:We reviewed the article with the theme article is stem cell and regenerative medicine. Stem cell therapy consistently demonstrated remarkable efficacy in promoting tissue regeneration. Across applications,stem cells showcased a remarkable versatility in enhancing tissue-specific cell behavior and activating regenerative pathways. his versatility positions stem cells as a promising tool with broad applications in regenerative medicine.

Conclusion:This review emphasize the versatility and efficacy of stem cellsin diverse regenerative scenarios. Evaluating methodological quality and comparing studies reveal nuanced insights, guiding future research directions. This review provides a comprehensive understanding of the current landscape, paving the way for innovative approaches in regenerative medicine.

Keywords:Stem cell therapy, Regenerative medicine, Literature review, Tissue engineering, Cell-based therapies

Regenerative medicine and stem cell-based therapies have shown great potential in accelerating tissue repair, reducing inflammation, and improving outcomes for patients with otherwise limited treatment options.

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References

1. Medhat A, El-Zainy MA, Fathy I. Photo Biomodulation of Dental Derived Stem Cells to Ameliorate Regenerative Capacity. Saudi DentJ. 2023;9:1724.

2. Rydström A, Grahn THM, Niroula A, Mansell E, van der Garde M, Pertesi M, et al. Functional and molecular profiling of hematopoietic stem cells during regeneration. Exp Hematol. 2023;127:40–51.

3. Nguyen-Thi TD, Nguyen-Huynh BH, Vo-Hoang TT, Nguyen-Thanh T. Stem cell therapies for periodontal tissue regeneration: A meta-analysis of clinical trials. J Oral Biol Craniofac Res. 2023;13(5):589–97.

4. Wu H, Tan J, Sun D, Wang X, Shen J, Wang S, et al. Discovery of multipotent progenitor cells from human induced membrane: Equivalent to periosteum-derived stem cells in bone regeneration. JOrthopTranslat. 2023;42(August):82–93.

5. Bywall KS, Drevin J, Groothuis-Oudshoorn C, Veldwijk J, Nyholm D, Widner H, et al. Patients accept therapy using embryonic stem cells for Parkinson’s disease: a discrete choice experiment. BMC MedEthics. 2023;24(1):1–13.

6. Menasché P, Vanneaux V, Hagège A, Bel A, Cholley B, Parouchev A, et al. Transplantation of Human Embryonic Stem Cell–Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction. JAmCollof Cardiol. 2018;71(4):429–38.

7. Shroff G. Use of Human Embryonic Stem Cells in the Treatment of Diabetes Mellitus: A Case Series. JDiabetes Mellit. 2015;05(04):313–8.

8. Yamanaka S. Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges. Cell Stem Cell. 2020;27(4):523-531.

9. Shaffiey SA, Jia H, Keane T, Costello C, Wasserman D, QuidgleyM, et al. Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals. Regen Med. 2016;11(1):45–61.

10. Matsumoto D, Toba H, Kenzaki K, Sakiyama S, Sakamoto S, Takashima M, et al. Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids. Regen Ther. 2023;24:426–33.

11. Harris VK, Stark J, Vyshkina T, Blackshear L, Joo G, Stefanova V, et al. Phase I Trial of Intrathecal Mesenchymal Stem Cell-derived Neural Progenitors in Progressive Multiple Sclerosis. EBioMedicine. 2018;29:23–30.

12. Vaquero J, Zurita M, Rico MA, Aguayo C, Bonilla C, Marin E, et al. Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: Safety and efficacy of the 100/3 guideline. Cytotherapy. 2018;20(6):806–19.

13. Honmou O, Yamashita T, Morita T, Oshigiri T, Hirota R, Iyama S, et al. Intravenous infusion of auto serum-expanded autologous mesenchymal stem cellsin spinal cord injury patients: 13 case series. ClinNeurolNeurosurg. 2021;203:106565.

14. Yang S, Zhang Y, Peng Q, Meng B, Wang J, Sun H, et al. Biomedicine & Pharmacotherapy Regulating pyroptosis by mesenchymal stem cellsand extracellular vesicles : A promising strategy to alleviate intervertebral disc degeneration. BiomedPharmacother. 2024;170:116001.

15. Zhou L, Wang H, Shen D, Xiang J, Yu N, He X, et al. Stem cells implanted with nanofibrous mats for injured endometrial regeneration and immune-microenvironment remodeling. Materials Today Bio. 2023;23:100855.

16. Ma D, Xu K, Zhang G, Liu Y, Gao J, Tian M, et al. Immunomodulatory effect of human umbilical cord mesenchymal stem cells on T lymphocytes in rheumatoid arthritis. IntImmunopharmacol. 2019;74:105687.

17. Pan C, Liu P, Ma D, Zhang S, Ni M, Fang Q, et al. Bone marrow mesenchymal stem cells in microenvironment transform into cancer-associated fibroblasts to promote the progression of B-cell acute lymphoblastic leukemia. BiomedPharmacother. 2020;130:110610.

18. Arakawa M, Sakamoto Y, Miyagawa Y, Nito C, Takahashi S, Nitahara-Kasahara Y, et al. iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress. MolTherMethods ClinDev. 2023;30:333–49.

19. Mahla RS. Stem cells applications in regenerative medicine and disease therapeutics. Int JCell Biol. 2016;2016: 6940283.

20. Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinicalprogress. NPJRegenMed. 2019;4:22.

21. HoangDM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Signal TransductTargetTher. 2022;7:272.

22. Al Abbar A, Ngai SC, Nograles N, Alhaji SY, Abdullah S. Induced Pluripotent Stem Cells: Reprogramming Platforms and Applications in Cell Replacement Therapy. BioResearch Open Access. 2020;9(1):121–36.

23. Zhong C, Liu M, Pan X, Zhu H. Tumorigenicity risk of iPSCs in vivo: nip it in the bud. PrecisClinMed. 2022;5(1):1–11.

24. Poulos J. The limited application of stem cells in medicine: A review. Stem Cell ResTher. 2018;9(1):1–11.

25. Petrus-Reurer S, Romano M, Howlett S, Jones JL, Lombardi G, Saeb-Parsy K. Immunological considerations and challenges for regenerative cellular therapies. CommunBiol. 2021;4(1):798.

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